Table 3.
Mean (SD) and F-value for main outcomes by condition and visit.
| Outcome | Measured DLMO (M-DLMO) | Estimated DLMO (E-DLMO) | Condition × Visit Interaction (F-value) | Visit Effect (F-value) | ||
|---|---|---|---|---|---|---|
| Pretreatment (n = 20) | Post-treatment (n = 19) | Pretreatment (n = 20) | Post-treatment (n = 18) | |||
| Dim light melatonin onset (hh:mm)‡ | 22:54 (2:13) | 21:48 (1:13) | 22:33 (1:31) | 20:37 (1:20) | 1.35 | 33.06*** |
| Morningness-Eveningness Questionnaire† | 35.85 (7.1) | 41.78 (6.2) | 32.2 (6.4) | 43.7 (10.8) | 6.66 | 46.38*** |
| Multidimensional Fatigue Inventory† | 12.6 (3.8) | 10.6 (4.0) | 12.2 (3.0) | 9.8 (3.8) | 0.20 | 13.83*** |
| PROMIS–Sleep Disturbance† | 50.1 (7.0) | 44.5 (7.3) | 51.1 (7.7) | 43.6 (5.8) | 0.57 | 22.68*** |
| PROMIS–Sleep Related Impairment† | 54.9 (7.6) | 49.1 (6.3) | 56.0 (7.3) | 46.6 (8.6) | 1.40 | 23.15*** |
| Pittsburgh Sleep Quality Index† | 5.4 (2.4) | 6.7 (2.6) | 6.9 (3.6) | 5.8 (2.3) | 4.34 | 0.13 |
| Diary | ||||||
| Total sleep time (h) | 6.9 (0.6) | 7.2 (0.7) | 6.8 (1.0) | 7.3 (0.7) | 0.45 | 9.14 |
| Sleep-onset time (hh:mm) | 02:19 (1:55) | 00:44 (1:34) | 01:45 (2:05) | 00:01 (1:41) | 0.12 | 72.64*** |
| Sleep-offset time (hh:mm) | 09:45 (1:50) | 08:31 (1:19) | 09:20 (1:46) | 08:02 (1:47) | 0.27 | 61.20*** |
| Actigraphy | ||||||
| Total sleep time (h) | 6.5 (0.7) | 7.0 (0.8) | 6.3 (0.8) | 6.9 (0.9) | 0.01 | 17.34*** |
| Sleep-onset time (hh:mm) | 02:37 (1:59) | 01:08 (1:23) | 02:20 (1:40) | 00:56 (1:51) | 0.01 | 51.24*** |
| Sleep-offset time (hh:mm) | 09:50 (1:41) | 08:41 (1:21) | 09:32 (1:54) | 08:13 (1:36) | 0.57 | 54.69*** |
†Post-treatment M-DLMO condition, n = 18, due to missing data from 1 participant. ‡Sample sizes are as follows: pretreatment E-DLMO condition, n = 15; post-treatment E-DLMO condition, n = 14; pretreatment M-DLMO condition, n = 20; post-treatment M-DLMO, n = 18. ***P < .001. DLMO = dim light melatonin onset, PROMIS = Patient-Reported Outcome Measurement Information System, SD = standard deviation.