Table 1.

Narcolepsy diagnostic criteria according to the International Classification of Sleep Disorders, third edition, text revision.³

Narcolepsy: Patient experiences excessive daytime sleepiness—daily bouts of uncontrollable drowsiness or an overpowering urge to sleep—happening for ≥ 3 months. The symptoms are not attributed to chronic lack of sleep, circadian disruptions, mental disorders, OSA, medication or substance use side effects/withdrawal symptoms.
Narcolepsy Type 1:	Narcolepsy Type 2:
Required symptoms: Excessive daytime sleepiness Cataplexy	Required symptoms: Excessive daytime sleepiness No cataplexy
Required diagnostic test findings: At least 1 of the following: Either: Mean sleep latency ≤ 8 minutes and ≥ 2 SOREMPs as determined by MSLT. A SOREMP in the first 15 minutes of sleep, as observed during the nocturnal polysomnogram. CSF hypocretin-1 ≤ 110 pg/ml or < 1/3 of the mean levels observed in healthy participants using the same assay.	Required diagnostic test findings: Mean sleep latency ≤ 8 minutes and ≥ 2 SOREMPs as determined by MSLT. (Note: A SOREMP in the first 15 minutes of sleep on the previous nocturnal PSG may replace 1 of the SOREMPs on the MSLT). CSF hypocretin-1 > 110 pg/ml or > 1/3 of the mean levels observed in healthy participants using the same assay.

Presence of these diagnostic criteria is not reflected in MarketScan database. Diagnostic criteria from International Classification of Sleep Disorders, third edition, text revision are copyright of the American Academy of Sleep Medicine and used here with permission. CSF = cerebrospinal fluid, MSLT = Multiple Sleep Latency Test, SOREMP = sleep onset rapid eye movement sleep periods, OSA = obstructive sleep apnea.