Table 3.
Follow-up cognitive function test data of patients with iRBD.
| Memory | Visuospatial Function | Executive Function | Global Cognition, MMSE-DS | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| DSF | DSB | WLR | CR | CP | CLOX2 | TMT-A | TMT-B | VFT | SCWT | FAB | ||
| Group 1 (n = 14) | ||||||||||||
| Pre | 0.20 (0.97) | −0.05 (0.68) | −0.04 (1.00) | 0.28 (0.96) | 0.30 (0.48) | 0.27 (0.42) | 1.05 (0.54) | 0.75 (0.96) | 0.21 (1.24) | −0.07 (1.05) | 0.28 (0.75) | −0.92 (1.55) |
| Post | −0.16 (0.94) | −0.03 (1.08) | −0.63 (1.17) | 0.03 (1.03) | −0.26 (1.02) | 0.22 (0.49) | 0.88 (0.47) | 0.49 (1.11) | 0.17 (0.92) | −0.03 (0.84) | −0.03 (1.23) | −0.07 (1.21) |
| P | .115 | .918 | .065 | .299 | .03 | .465 | .354 | .326 | .878 | .706 | .466 | .006 |
| Group 2 (n = 20) | ||||||||||||
| Pre | 0.12 (0.97) | 0.29 (1.09) | 0.32 (0.89) | 0.37 (1.04) | 0.05 (0.93) | 0.24 (0.43) | 0.79 (0.41) | 0.04 (1.68) | 0.52 (1.05) | 0.51 (0.89) | 0.18 (0.78) | −0.34 (0.87) |
| Post | 0.16 (1.04) | 0.08 (1.14) | 0.21 (0.98) | 0.20 (0.70) | 0.10 (0.92) | 0.45 (0.13) | 0.71 (0.75) | 0.08 (1.58) | 0.10 (0.84) | 0.42 (0.80) | 0.61 (0.83) | −0.14 (1.40) |
| P | .872 | .400 | .555 | .936 | .773 | .042 | .936 | .653 | .08 | .709 | .026 | .435 |
| Group 3 (n = 32) | ||||||||||||
| Pre | 0.23 (0.84) | 0.56 (1.24) | −0.07 (1.02) | 0.15 (0.89) | 0.32 (0.53) | 0.31 (0.45) | 0.99 (0.51) | 0.81 (1.46) | 0.63 (1.35) | 0.40 (1.04) | 0.29 (0.68) | −0.14 (0.92) |
| Post | 0.40 (0.98) | 0.00 (1.11) | −0.53 (0.98) | −0.06 (0.90) | 0.45 (0.47) | 0.40 (0.23) | 0.63 (0.73) | 0.67 (1.19) | 0.65 (1.03) | 0.31 (1.07) | 0.09 (0.84) | 0.08 (0.83) |
| P | .299 | .004* | .022 | .158 | .088 | .022 | .001* | .437 | .918 | .492 | .198 | .175 |
| Group 4 (n = 35) | ||||||||||||
| Pre | 0.64 (0.81) | 0.57 (1.41) | −0.04 (0.81) | −0.02 (0.75) | 0.28 (0.45) | 0.14 (0.84) | 0.88 (0.67) | 0.79 (1.10) | 0.47 (1.21) | 0.32 (0.95) | 0.38 (0.72) | −0.76 (1.39) |
| Post | 0.49 (0.92) | 0.17 (1.15) | −0.27 (0.75) | −0.10 (0.97) | 0.20 (0.65) | 0.27 (0.87) | 0.67 (0.56) | −0.08 (1.55) | 0.31 (1.07) | 0.18 (0.96) | 0.24 (0.80) | −0.25 (1.04) |
| P | .626 | .041 | .069 | .746 | .828 | .017 | .004* | .001* | .407 | .19 | .475 | .025 |
| Group × time effect P | .243 | .334 | .398 | .942 | .038 | .497 | .352 | .035 | .561 | .911 | .106 | .274 |
| Group effect P | .112 | .646 | .096 | .348 | .106 | .653 | .673 | .231 | .453 | .392 | .550 | .219 |
| Time effect P | .420 | .014 | .001* | .139 | .161 | .062 | .001* | .023 | .212 | .407 | .600 | < .001* |
Paired t test or Wilcoxon signed rank test were performed for differences between pre- and post-cognitive functions in each group. Repeated measures analysis of variance (RM ANOVA) was conducted to confirm group by time interaction. P values reaching statistical significance are shown in bold. *The adjusted significance level for multiple comparisons was set to .0042 with Bonferroni correction. CLOX2 = Clock Drawing Test 2, CP = Constructional Praxis test, CR = Constructional Recall test, DSB = Digit Span Backward test, DSF = Digit Span Forward test, FAB = Frontal Assessment Battery, iRBD = isolated rapid eye movement sleep behavior disorder, MMSE-DS = Mini-Mental State Examination–Dementia Screening, SCWT = Stroop Color and Word Test, TMT-A = Trail Making Test A, TMT-B = Trail Making Test B, VFT = Verbal Fluency Test, WLR = Word List Recall test.