Table 2. Effect of letrozole alone and in combination with CoQ10 on sperm concentration.
| Sperm parameters | Group A | Group B | P value A | |
|---|---|---|---|---|
| Mean ± SD | Mean ± SD | |||
| Volume (ml) | Baseline | 3.1 ± 1 a | 3.1 ± 0.9 a | 0.975 NS |
| First month | 2.6 ± 0.9 b | 3 ± 0.8 a | 0.058 NS | |
| Second month | 2.7 ± 0.7 ab | 3.1 ± 1.1 a | 0.048 * | |
| Third month | 3 ± 1 ab | 3.1 ± 1 a | 0.722 NS | |
| P value B | 0.044 * | 0.769 NS | ||
| Sperm concentration (Mil./ml) | Baseline | 8.9 ± 7.9 a | 7.3 ± 5.2 a | 0.305 NS |
| First month | 14.1 ± 11.9 b | 11.9 ± 9.2) b | 0.369 NS | |
| Second month | 17.2 ± 14.1 c | 20 ± 14.1 c | 0.392 NS | |
| Third month | 16.5 ± 11.9 d | 25.2 ± 16.5 d | 0.020 * | |
| P value B | < 0.001 ** | < 0.001 ** | ||
| Total sperm count (Million) | Baseline | 26.8 ± 22.4 a | 24.8 ± 20.6 a | 0.689 NS |
| First month | 35 ± 25.8 ab | 36.5 ± 32 b | 0.818 NS | |
| Second month | 46.3 ± 39.7 c | 66 ± 60.4 c | 0.392 NS | |
| Third month | 52.9 ± 48.8 ad | 80.1 ± 62.6 cd | 0.029 * | |
| P value B | 0.005 ** | < 0.001 ** | ||
Data presented as mean ± SD.
A
t-test used to test statistical differences between 2 groups (Horizontally).
B
One-way repeated measures ANOVA was used for comparison. Different letters indicate significant difference (a vs. b <0.05, a vs. c <0.05, a vs. d <0.05, b vs. c <0.05, b vs. d <0.05, c vs. d <0.05). NS: No significant changes (p≥0.05).
*
significant changes (p<0.05).
**
highly significant changes (p<0.01). CoQ10, coenzyme Q10.