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. 2015 Jun 3;2015(6):CD010432. doi: 10.1002/14651858.CD010432.pub2

Comparison 2. IDA versus MIT.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 OS‐overall analysis 6 2171 Hazard Ratio (Fixed, 95% CI) 0.98 [0.89, 1.08]
2 OS‐sensitivity analysis by random‐effects model 6 2171 Hazard Ratio (Random, 95% CI) 0.97 [0.83, 1.12]
3 OS‐sensitivity analysis by excluding studies with high risk of bias 5 2115 Hazard Ratio (Fixed, 95% CI) 1.01 [0.92, 1.11]
4 OS‐subgroup analysis by dose of IDA 6   Hazard Ratio (Fixed, 95% CI) Subtotals only
4.1 8 mg/m²/d 2 220 Hazard Ratio (Fixed, 95% CI) 1.06 [0.81, 1.39]
4.2 10 mg/m²/d 2 1663 Hazard Ratio (Fixed, 95% CI) 0.99 [0.89, 1.11]
4.3 12 mg/m²/d 2 288 Hazard Ratio (Fixed, 95% CI) 0.90 [0.73, 1.11]
5 OS‐subgroup analysis by age 2   Hazard Ratio (Fixed, 95% CI) Subtotals only
5.1 ≥ 15 years to < 60 years 1 1436 Hazard Ratio (Fixed, 95% CI) 0.99 [0.88, 1.11]
5.2 ≥ 60 years 1 160 Hazard Ratio (Fixed, 95% CI) 1.03 [0.75, 1.41]
6 DFS‐overall analysis 4 249 Hazard Ratio (Fixed, 95% CI) 0.88 [0.70, 1.10]
7 DFS‐sensitivity analysis by random‐effects model 4 249 Hazard Ratio (Random, 95% CI) 0.86 [0.62, 1.21]
8 DFS‐subgroup analysis by dose of IDA 4   Hazard Ratio (Fixed, 95% CI) Subtotals only
8.1 8 mg/m²/d 2 123 Hazard Ratio (Fixed, 95% CI) 1.06 [0.75, 1.50]
8.2 12 mg/m²/d 2 126 Hazard Ratio (Fixed, 95% CI) 0.75 [0.55, 1.02]
9 CR‐overall analysis 8 2411 Risk Ratio (M‐H, Fixed, 95% CI) 0.97 [0.92, 1.03]
10 CR‐sensitivity analysis by random‐effects model 8 2411 Risk Ratio (M‐H, Random, 95% CI) 0.97 [0.92, 1.02]
11 CR‐subgroup analysis by dose of IDA 6   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
11.1 8 mg/m²/d 2 220 Risk Ratio (M‐H, Fixed, 95% CI) 0.88 [0.70, 1.11]
11.2 10 mg/m²/d 2 1663 Risk Ratio (M‐H, Fixed, 95% CI) 0.95 [0.90, 1.02]
11.3 12 mg/m²/d 2 295 Risk Ratio (M‐H, Fixed, 95% CI) 0.99 [0.80, 1.24]
12 CR‐subgroup analysis by age 3   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
12.1 ≥ 15 years to < 60 years 2 1490 Risk Ratio (M‐H, Fixed, 95% CI) 0.96 [0.90, 1.03]
12.2 ≥ 60 years 2 169 Risk Ratio (M‐H, Fixed, 95% CI) 0.91 [0.71, 1.18]
13 Death on induction therapy‐overall analysis 5 2055 Risk Ratio (M‐H, Fixed, 95% CI) 1.10 [0.88, 1.38]
14 Death on induction therapy‐sensitivity analysis by random‐effects model 5 2055 Risk Ratio (M‐H, Random, 95% CI) 1.10 [0.88, 1.38]
15 Death on induction therapy‐subgroup analysis by dose of IDA 4   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
15.1 8 mg/m²/d 1 160 Risk Ratio (M‐H, Fixed, 95% CI) 0.8 [0.33, 1.92]
15.2 10 mg/m²/d 1 1436 Risk Ratio (M‐H, Fixed, 95% CI) 1.06 [0.81, 1.38]
15.3 12 mg/m²/d 2 295 Risk Ratio (M‐H, Fixed, 95% CI) 1.48 [0.90, 2.43]
16 Death on induction therapy‐subgroup analysis by age 2   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
16.1 ≥ 15 years to < 60 years 1 1436 Risk Ratio (M‐H, Fixed, 95% CI) 1.06 [0.81, 1.38]
16.2 ≥ 60 years 1 160 Risk Ratio (M‐H, Fixed, 95% CI) 0.8 [0.33, 1.92]
17 Relapse‐overall analysis 3 328 Risk Ratio (M‐H, Fixed, 95% CI) 0.99 [0.80, 1.22]
18 Relapse‐sensitivity analysis by random‐effects model 3 328 Risk Ratio (M‐H, Random, 95% CI) 0.97 [0.80, 1.19]
19 Relapse‐subgroup analysis by dose of IDA 3   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
19.1 8 mg/m²/d 1 95 Risk Ratio (M‐H, Fixed, 95% CI) 1.07 [0.75, 1.53]
19.2 10 mg/m²/d 1 187 Risk Ratio (M‐H, Fixed, 95% CI) 0.96 [0.68, 1.37]
19.3 12 mg/m²/d 1 46 Risk Ratio (M‐H, Fixed, 95% CI) 0.91 [0.66, 1.26]
20 Nausea/vomiting grade 3/4‐overall analysis 3 387 Risk Ratio (M‐H, Fixed, 95% CI) 1.03 [0.66, 1.61]
21 Nausea/vomiting grade 3/4‐sensitivity analysis by random‐effects model 3 387 Risk Ratio (M‐H, Random, 95% CI) 1.04 [0.67, 1.63]
22 Nausea/vomiting grade 3/4‐subgroup analysis by dose of IDA 2   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
22.1 8 mg/m²/d 1 160 Risk Ratio (M‐H, Fixed, 95% CI) 0.8 [0.22, 2.87]
22.2 12 mg/m²/d 1 63 Risk Ratio (M‐H, Fixed, 95% CI) 0.85 [0.13, 5.68]
23 Diarrhoea grade 3/4‐overall analysis 2 223 Risk Ratio (M‐H, Fixed, 95% CI) 1.41 [0.68, 2.89]
24 Diarrhoea grade 3/4‐sensitivity analysis by random‐effects model 2 223 Risk Ratio (M‐H, Random, 95% CI) 1.40 [0.68, 2.88]
25 Diarrhoea grade 3/4‐subgroup analysis by dose of IDA 2   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
25.1 8 mg/m²/d 1 160 Risk Ratio (M‐H, Fixed, 95% CI) 1.33 [0.60, 2.99]
25.2 12 mg/m²/d 1 63 Risk Ratio (M‐H, Fixed, 95% CI) 1.71 [0.34, 8.65]
26 Hepatic toxicity grade 3/4‐overall analysis 2 324 Risk Ratio (M‐H, Fixed, 95% CI) 1.22 [0.47, 3.17]
27 Hepatic toxicity grade 3/4‐sensitivity analysis by random‐effects analysis 2 324 Risk Ratio (M‐H, Random, 95% CI) 1.21 [0.47, 3.16]
28 Renal toxicity grade 3/4‐overall analysis 2 223 Risk Ratio (M‐H, Fixed, 95% CI) 0.31 [0.03, 2.91]
29 Renal toxicity grade 3/4‐sensitivity analysis by random effects model 2 223 Risk Ratio (M‐H, Random, 95% CI) 0.31 [0.03, 2.91]
30 Renal toxicity grade 3/4‐subgroup analysis by dose of IDA 2   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
30.1 8 mg/m²/d 1 160 Risk Ratio (M‐H, Fixed, 95% CI) 0.33 [0.01, 8.06]
30.2 12 mg/m²/d 1 63 Risk Ratio (M‐H, Fixed, 95% CI) 0.29 [0.01, 6.76]
31 Mucositis grade 3/4‐overall analysis 2 223 Risk Ratio (M‐H, Fixed, 95% CI) 1.89 [0.36, 9.92]
32 Mucositis grade 3/4‐sensitivity analysis by random‐effects model 2 223 Risk Ratio (M‐H, Random, 95% CI) 1.81 [0.32, 10.21]
33 Mucositis grade 3/4‐subgroup analysis by dose of IDA 2   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
33.1 8 mg/m²/d 1 160 Risk Ratio (M‐H, Fixed, 95% CI) 3.0 [0.32, 28.23]
33.2 12 mg/m²/d 1 63 Risk Ratio (M‐H, Fixed, 95% CI) 0.85 [0.06, 13.04]
34 Infection grade 3/4‐overall analysis 2 1663 Risk Ratio (M‐H, Fixed, 95% CI) 1.04 [0.91, 1.19]
35 Infection grade 3/4‐sensitivity analysis by random‐effects analysis 2 1663 Risk Ratio (M‐H, Random, 95% CI) 1.16 [0.78, 1.72]