Table 3.
Baseline Characteristics for Patients Diagnosed With ATTR-CA Divided by the Percent Predicted 6MWT Distance Quartile
| 6MWT Percent Predicted Quartiles |
P Value | ||||
|---|---|---|---|---|---|
| >89% (n = 546) | 75%-89% (n = 522) | 55%-74% (n = 546) | <55% (n = 527) | ||
| Baseline characteristics | |||||
| Age, y | 75.9 ± 7.9c | 75.6 ± 8.5e | 76.1 ± 9.1f | 78.3 ± 7.8 | <0.001 |
| Male | 491 (89.8)c | 468 (89.7)e | 496 (90.8)f | 430 (81.6) | <0.001 |
| Ethnicity | <0.001 | ||||
| White | 474 (86.8)c | 455 (87.2)e | 444 (81.3)f | 386 (73.2) | |
| Afro-Caribbean | 65 (11.9)b,c | 60 (11.5)d,e | 96 (17.6)f | 132 (25.0) | |
| Asian | 4 (0.7) | 6 (1.1) | 5 (0.9) | 6 (1.1) | |
| Other | 3 (0.5) | 1 (0.2) | 1 (0.2) | 3 (0.6) | |
| Genotypes | <0.001 | ||||
| wtATTR | 431 (78.9)c | 396 (75.9)e | 402 (73.6)f | 344 (65.3) | |
| p.(V142I) hATTR | 52 (9.5)c | 48 (9.2)e | 77 (14.2)f | 115 (21.8) | |
| Non-p.(V142I) hATTR | 63 (11.5) | 78 (14.9) | 67 (12.3) | 68 (12.9) | |
| Heart failure severity | |||||
| NYHA functional class | <0.001 | ||||
| I | 126 (23.1)a,b,c | 71 (13.6)d | 52 (9.5) | 33 (6.3) | |
| II | 372 (68.1)c | 343 (65.7)e | 371 (67.9)f | 282 (53.5) | |
| III | 32 (5.8)a,b,c | 56 (10.7)e | 78 (14.2)f | 167 (31.7) | |
| IV | 0 (0.0)c | 0 (0.0)e | 3 (0.5) | 10 (1.9) | |
| Missing | 16 | 52 | 42 | 35 | |
| 6MWT distance, m | 460 (414-515)a,b,c | 391 (351-432)d,e | 310 (276-349)f | 161 (92-211) | <0.001 |
| Systolic blood pressure, mm Hg | 128.3 ± 17.3b,c | 126.0 ± 17.1 | 125.2 ± 16.8 | 123.9 ± 17.8 | <0.001 |
| Diastolic blood pressure, mm Hg | 76.0 ± 9.9c | 75.4 ± 10.5e | 75.0 ± 10.2 | 73.5 ± 10.0 | 0.001 |
| Heart rate, beats/min | 70.1 ± 13.5b | 71.9 ± 12.7 | 72.9 ± 12.7 | 72.5 ± 12.4 | 0.011 |
| Blood biomarkers | |||||
| NAC stage | <0.001 | ||||
| 1 | 365 (66.8)a,b,c | 287 (55.0)e | 265 (48.5)f | 178 (33.8) | |
| 2 | 131 (24.0)a,b,c | 184 (35.2) | 210 (38.5) | 207 (39.3) | |
| 3 | 50 (9.2)c | 51 (9.8)e | 71 (13.0)f | 142 (26.9) | |
| NT-proBNP, ng/L | 1,785 (940-3,281)a,b,c | 2,476 (1,311-4,134)e | 2,764 (1,357-4,796)f | 3,577 (2,009-6,475) | <0.001 |
| eGFR, mL/min/1.73 m2 | 63 (53-78)b,c | 63 (50-72)e | 59 (48-74)f | 52 (40-66) | <0.001 |
| Hemoglobin, g/L | 142 (132-151)b,c | 140 (129-149)d,e | 137 (126-146)f | 132 (120-143) | <0.001 |
| Serum total bilirubin, μmol/L | 12 (9-17)b,c | 13 (9-18) | 13 (9-19) | 13 (9-19) | 0.005 |
| Alanine transaminase, IU/L | 26 (20-34)c | 25 (19-34)e | 25 (19-32) | 24 (18-31) | <0.001 |
| Alkaline phosphatase, IU/L | 83 (68-105)b,c | 89 (70-114)d,e | 93 (73-125) | 101 (76-140) | <0.001 |
| GGT, IU/L | 54 (28-105)b,c | 65 (32-118)e | 70 (32-143)f | 84 (38-185) | <0.001 |
| Echocardiographic parameters | |||||
| IVSd, mm | 16.6 ± 2.6 | 17.0 ± 2.7 | 16.8 ± 2.6 | 16.7 ± 2.4 | 0.035 |
| PWTd, mm | 16.1 ± 2.7 | 16.5 ± 2.6 | 16.4 ± 2.7 | 16.3 ± 2.5 | 0.048 |
| LVEF, % | 51.2 ± 10.2a,b,c | 49.0 ± 10.5e | 48.5 ± 11.0 | 47.1 ± 10.7 | <0.001 |
| Longitudinal strain, % | –12.0 ± 4.0b,c | –11.5 ± 3.8e | –11.0 ± 3.8 | –10.4 ± 3.6 | <0.001 |
| E/e′ | 15.3 ± 7.1a,b,c | 16.5 ± 6.6e | 17.0 ± 7.9 | 17.1 ± 7.0 | <0.001 |
Values are mean ± SD, n (%), n, or median (Q1-Q3). P values for pairwise comparison.
Abbreviations as in Table 1.
a
P < 0.05 for >89% vs 75%-89%.
b
P < 0.05 for >89% vs 55%-74%.
c
P < 0.05 for >89% vs <55%.
d
P < 0.05 for 75%-89% vs 55%-74%.
e
P < 0.05 for 75%-89% vs <55%.
f
P < 0.05 for 55%-74% vs <55%.