Table 2.
Protein EpiScores associated with birth gestational age
| Chemokines | Growth factors | Neurogenesis | Vascular development | Cell membrane proteins/receptors | Other immune response |
|---|---|---|---|---|---|
| CCL11 | FGF21 | NCAM1 | SKR3 | Afamin | Complement C9 |
| CCL18 | GDF15 | Semaphorin 3E | VCAM1 | CD5L | CRP |
| CCL21 | GHR | SLITRK5 | VEGFA | CD6 | CRTAM |
| CCL22 | HGF | CD48 | FAP | ||
| CCL25 | IGFBP4 | CD163 | HCII | ||
| CXCL9 | SCGF alpha | CD209 | L-selectin | ||
| CXCL10 | SCGF beta | Contactin-4 | Lactotransferrin | ||
| WFIKKN2 | FcRL2 | MMP9 | |||
| FcGR3B | S100A9 | ||||
| PIGR | Sialoadhesin | ||||
| Thrombopoeitin receptor | Trypsin-2 |
Forty-three EpiScores associated with birth gestational age in regression models adjusted for socioeconomic status. Roles adapted from the STRING database [62]. See Supplementary Table 4, Additional File 1, for further details of the functional roles of each protein, including roles in immunity and inflammation, and in preterm infants specifically
CCL11 C-C chemokine 11, CCL18 C-C chemokine 18, CCL21 C-C chemokine 21, CCL22 C-C chemokine 22, CCL25 C-C chemokine 25, CD5L CD5 antigen-like protein, CD6 T-cell differentiation antigen, CD163 Scavenger receptor cysteine-rich type 1 protein M130, CRP C-reactive protein, CRTAM cytotoxic and regulatory T-cell molecule, CXCL9 C-X-C motif chemokine 9, CXCL10 C-X-C motif chemokine 10, FAP fibroblast activation protein alpha, FCGR3B low-affinity immunoglobulin gamma Fc region receptor III-B, FcRL2 Fc receptor-like protein 2, FGF21 fibroblast growth factor 21, GDF15 growth/differentiation factor 15, GHR growth hormone receptor, HCII heparin cofactor II, HGF hepatocyte growth factor alpha chain, IGFBP4 insulin-like growth factor-binding protein 4, MMP9 matrix metalloproteinase-9, NCAM1 neural cell adhesion molecule 1, PIGR polymeric immunoglobulin receptor, SCGF stem cell growth factor, SIMD Scottish Index of Multiple Deprivation, SKR3 serine/threonine protein kinase receptor R3, SLITRK5 SLIT and NTRK-like protein 5, VCAM1 vascular cell adhesion protein 1, VEGFA vascular endothelial growth factor A, WFIKKN2 WAP Kazal immunoglobulin Kunitz and NTR domain-containing protein 2