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. 2024 Jul 2;19:85. doi: 10.1186/s13014-024-02480-z

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — RT-qPCR analysis of selected mRNAs related to DNA-damage (green), DNA-repair (cyan), DNA replication (blue) and cell cycle (red) in LNCaP (left) and DU145 cells (right). A Overview of the changes of mRNA levels (ΔΔCt, mean, n = 3) upon photon and ¹²C-ion irradiations with all tested doses and time points. B Subsets of changes of mRNA levels (ΔΔCt) (mean ± SD, n = 3) in adjusted scales displayed for the irradiation modes with the maximum applied dose for photons (12 Gy) and for ¹²C-ions (4 Gy). Significant differences (2-way-ANOVA with multiple comparisons) are indicated for each time point (separated by slash) in the insets. C Changes of mRNA levels (ΔΔCt) after DHT treatment (20 nM; 24 h) of LNCaP cells for analysis of mRNAs related to DNA-damage (green), DNA-repair (cyan), DNA replication (blue), cell cycle (red) in addition to androgen receptor (AR) signaling (black). The changes of mRNA levels (ΔΔCt) are displayed (mean ± SD, n = 3). Significant differences between DHT and control were determined by unpaired Welch corrected t-test. Symbols of significances (*p < 0.05, **p < 0.01; ***p < 0.001; ****p < 0.0001)