Table 2.
Results of linear regression predicting subjective cognitive concerns
| European Ancestry | African Ancestry | Hispanic Ancestry | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Beta | (SE) | t-value | p-value | Beta | (SE) | t-value | p-value | Beta | (SE) | t-value | p-value | |
| Age 45–54 | n = 10,286 | n = 2,957 | n = 1,227 | |||||||||
| Age | -0.004 | (.003) | -1.332 | 0.183 | 0.003 | (.006) | 0.512 | 0.608 | -0.003 | (.009) | -0.357 | 0.721 |
| Sex | 0.021 | (.021) | 1.010 | 0.313 | 0.015 | (.039) | 0.384 | 0.701 | 0.111 | (.071) | 1.561 | 0.119 |
| Smoking | -0.016 | (.017) | -0.952 | 0.341 | -0.005 | (.035) | -0.144 | 0.886 | -0.035 | (.054) | -0.659 | 0.510 |
| Heavy Alcohol Use | -0.000 | (.018) | -0.017 | 0.986 | -0.004 | (.039) | -0.090 | 0.928 | -0.082 | (.060) | -1.371 | 0.171 |
| Education | -0.027 | (.006) | -4.537 | 5.78E-06 | -0.036 | (.013) | -2.775 | 0.006 | -0.054 | (.020) | -2.675 | 0.008 |
| Probable TBI | 0.239 | (.024) | 9.929 | 3.97E-23 | 0.243 | (.077) | 3.178 | 0.002 | 0.398 | (.079) | 5.022 | 5.89E-07 |
| PTSD symptoms | 0.608 | (.008) | 78.639 | p < 1E-250 | 0.633 | (.014) | 46.323 | p < 1E-250 | 0.641 | (.022) | 28.963 | 1.67E-140 |
| APOE ε4 | -0.018 | (.016) | -1.128 | 0.259 | -0.015 | (.029) | -0.513 | 0.608 | -0.054 | (.058) | -0.935 | 0.350 |
| APOE ε4 x PTSD symptoms | 0.006 | (.015) | 0.428 | 0.669 | -0.036 | (.023) | -1.633 | 0.103 | -0.015 | (.048) | -0.312 | 0.755 |
| APOE ε4 x TBI | 0.035 | (.047) | 0.750 | 0.453 | 0.112 | (.116) | 0.969 | 0.333 | 0.073 | (.175) | 0.420 | 0.675 |
| Age 55–64 | n = 31,345 | n = 6,308 | n = 2,605 | |||||||||
| Age | -0.012 | (.002) | -7.226 | 5.08E-13 | -0.003 | (.004) | -0.764 | 0.445 | -0.006 | (.006) | -1.041 | 0.298 |
| Sex | 0.016 | (.015) | 1.018 | 0.309 | 0.050 | (.039) | 1.278 | 0.201 | -0.040 | (.065) | -0.611 | 0.541 |
| Smoking | -0.008 | (.010) | -0.775 | 0.438 | -0.056 | (.028) | -2.017 | 0.044 | -0.094 | (.038) | -2.489 | 0.013 |
| Heavy Alcohol Use | -0.050 | (.011) | -4.740 | 2.15E-06 | -0.077 | (.030) | -2.526 | 0.012 | -0.076 | (.041) | -1.857 | 0.063 |
| Education | -0.030 | (.003) | -8.804 | 1.39E-18 | -0.060 | (.010) | -6.012 | 1.94E-09 | -0.058 | (.014) | -4.236 | 2.35E-05 |
| Probable TBI | 0.146 | (.015) | 9.830 | 9.00E-23 | 0.182 | (.057) | 3.168 | 0.002 | 0.174 | (.068) | 2.557 | 0.011 |
| PTSD symptoms | 0.562 | (.005) | 120.478 | p < 1E-250 | 0.573 | (.011) | 52.805 | p < 1E-250 | 0.593 | (.015) | 39.499 | p < 1E-250 |
| APOE ε4 | 0.009 | (.009) | 0.929 | .353 | -0.030 | (.022) | -1.403 | 0.161 | 0.031 | (.040) | 0.757 | 0.449 |
| APOE ε4 x PTSD symptoms | -0.018 | (.009) | -1.543 | 0.055 | -0.004 | (.018) | -0.251 | 0.802 | 0.012 | (.034) | 0.337 | 0.736 |
| APOE ε4 x TBI | -0.009 | (.030) | -0.301 | 0.763 | 0.029 | (.101) | 0.285 | 0.776 | 0.005 | (.164) | 0.028 | 0.978 |
| Age 65 + | n = 101,667 | n = 6,985 | n = 4,360 | |||||||||
| Age | 0.010 | (.000) | 29.361 | 1.08E-188 | 0.014 | (.002) | 6.789 | 1.22E-11 | 0.011 | (.002) | 4.252 | 2.17E-05 |
| Sex | -0.015 | (.016) | -0.939 | 0.348 | 0.023 | (.065) | 0.355 | 0.723 | -0.053 | (.100) | -0.532 | 0.595 |
| Smoking | -0.010 | (.006) | -1.763 | 0.078 | -0.065 | (.027) | -2.431 | 0.015 | -0.007 | (.033) | -0.200 | 0.842 |
| Heavy Alcohol Use | -0.034 | (.006) | -6.027 | 1.68E-09 | 0.042 | (.031) | 1.330 | 0.184 | -0.060 | (.037) | -1.639 | 0.101 |
| Education | -0.038 | (.002) | -23.683 | 1.18E-123 | -0.057 | (.008) | -6.965 | 3.58E-12 | -0.083 | (.010) | -7.923 | 2.94E-15 |
| Probable TBI | 0.050 | (.010) | 5.252 | 1.51E-07 | 0.185 | (.058) | 3.157 | 0.002 | 0.187 | (.060) | 3.117 | 0.002 |
| PTSD symptoms | 0.500 | (.003) | 165.001 | p < 1E-250 | 0.507 | (.011) | 46.066 | p < 1E-250 | 0.517 | (.014) | 37.840 | p < 1E-250 |
| APOE ε4 | 0.037 | (.005) | 7.044 | 1.88E-12 | 0.013 | (.021) | 0.634 | 0.526 | 0.055 | (.034) | 1.632 | 0.103 |
| PTSD symptoms x APOE ε4 | 0.017 | (.006) | 2.741 | 0.006 | 0.019 | (.019) | 0.999 | 0.318 | 0.011 | (.030) | 0.351 | 0.725 |
| TBI x APOE ε4 | 0.017 | (.020) | 0.877 | 0.381 | 0.102 | (.106) | 0.957 | 0.339 | -0.045 | (.144) | -0.309 | 0.757 |
The parameter estimates for the main effects listed were derived from main effects-only models. The interaction term parameter estimates were from models with the main effects and interaction term included in the same model. Sex was coded such that males = 0 and females = 1
TBI traumatic brain injury, PTSD posttraumatic stress disorder