Table 3.

Results of Cox regression models predicting EMR-determined ADRD diagnoses

Variable	European Ancestry n = 90,548				African Ancestry n = 6,254				Hispanic Ancestry n = 3,861
		95.0% Cl				95.0% Cl				95.0% Cl
	HR	Lower	Upper	p	HR	Lower	Upper	p	HR	Lower	Upper	p
Age	1.11	1.10	1.11	p < 1e-250	1.12	1.10	1.14	1.37e-39	1.12	1.10	1.14	1.69E-30
Sex	1.17	0.95	1.44	0.134	0.65	0.27	1.58	0.340	1.66	0.72	3.80	0.231
Heavy alcohol use	0.74	0.68	0.81	7.88e-12	0.69	0.48	1.01	0.053	0.46	0.28	0.75	0.002
Smoking	1.01	0.94	1.09	0.775	1.22	0.93	1.60	0.147	0.87	0.64	1.17	0.362
Education	0.96	0.94	0.98	3.88e-05	0.98	0.91	1.07	0.710	1.07	0.97	1.18	0.156
Probable TBI	1.23	1.10	1.39	5.08e-04	1.55	0.97	2.48	0.066	1.34	0.81	2.20	0.256
PTSD symptoms	1.17	1.13	1.21	8.18e-17	1.23	1.07	1.41	0.003	1.26	1.07	1.48	0.005
APOE ε4	2.13	2.01	2.26	5.25e-143	1.85	1.54	2.23	6.89e-11	1.94	1.47	2.54	2.16E-06
SCC	1.37	1.33	1.41	2.37e-114	1.20	1.06	1.36	0.003	1.35	1.18	1.55	1.62E-05
PTSD symptoms x APOE ε4	0.93	0.87	0.98	0.01	0.98	0.82	1.17	0.791	0.81	0.61	1.08	0.154
TBI x APOE ε4	1.08	0.88	1.32	0.482	0.75	0.33	1.71	0.496	1.07	0.34	3.40	0.904
SCC x APOE ε4	0.98	0.94	1.02	0.302	0.91	0.76	1.09	0.297	0.90	0.71	1.15	0.418

Hazard ratio (HR) greater than one indicate elevated proportional risk for ADRD, and below one indicates reduced proportional risk for ADRD. The parameter estimates for the main effects listed were derived from main effects-only models. The interaction term parameter estimates were from models with the main effects and interaction term included in the same model. Analyses controlled for ancestry-specific principal components. Sex was coded such that males = 0 and females = 1

TBI traumatic brain injury, PTSD posttraumatic stress disorder, ADRD Alzheimer’s Disease and related dementias, SCC Subjective Cognitive Concerns