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. 2024 Jul 1;22:386. doi: 10.1186/s12951-024-02648-5

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 14 — (A) Schematic display of the method for synthesizing DNA-polymer conjugates with BKM120 encapsulated cargo, microscopic images of the cellular uptake in HeLa cells after 24-hour incubation (show high cellular uptake), and image of Cy5.5 fluorescence intensity at the tumor site 24 h after subcutaneous injection (showing long circulation and accumulation in tumors) [116]. (B) Schematic representation of DOX and CpG-loaded liposomal SNA (L-SNA) and its mechanism of function [118].

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