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. 2024 Jul 1;22:386. doi: 10.1186/s12951-024-02648-5

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 17 — The design of a delivery system containing adriamycin (Adr) and synthesized siRap2b conjugating with gold NPs. Treating drug-loaded GNs with an 808-nm laser generated a photothermal effect, which deeply enhanced drug release. The released drug (Adr) showed direct toxicity against cancer cells. Furthermore, isolated siRap2b remarkably diminished the expression of Rap2b and boosted anticancer therapeutic efficiency. Additionally, the thermal effects arising from laser directly suppressed cancer cells/tissues. This figure was redrawn with permission from ref [143]