TABLE 1.
MIC (μg/mL) of ME against a wide range of oral bacteria
| Groupa | Strain | MIC (µg/mL) |
|---|---|---|
| Periodontopathic bacteria (red) | Porphyromonas gingivalis ATCC 33277 | 250 |
| Periodontopathic bacteria (red) | P. gingivalis W83 | 125 |
| Periodontopathic bacteria (red) | P. gingivalis W50 | 250 |
| Periodontopathic bacteria (orange) | Prevotella nigrescens ATCC 33563 | 250 |
| Periodontopathic bacteria (orange) | Fusobacterium nucleatum no. 20 | 250 |
| Periodontopathic bacteria (NA) | Aggregatibacter actinomycetemcomitans Y4 (serotype b) | >500 |
| Periodontopathic bacteria (NA) | A. actinomycetemcomitans ATCC 29522 (serotype b) | >500 |
| Oral commensal bacteria (yellow) | Streptococcus anginosus ATCC 33397 | >500 |
| Oral commensal bacteria (yellow) | Streptococcus cristatus ATCC 51100 | >500 |
| Oral commensal bacteria (yellow) | Streptococcus gordonii ATCC 10558 | >500 |
| Oral commensal bacteria (yellow) | Streptococcus mitis ATCC 6245 | >500 |
| Oral commensal bacteria (yellow) | Streptococcus mutans UA159 | >500 |
| Oral commensal bacteria (yellow) | Streptococcus oralis no.10 | >500 |
| Oral commensal bacteria (yellow) | Streptococcus salivarius ATCC 9759 | >500 |
| Oral commensal bacteria (yellow) | Streptococcus sanguinis ATCC 10556 | >500 |
| Oral commensal bacteria (yellow) | Streptococcus sobrinus ATCC 6715 | >500 |
According to classification based on DNA-DNA hybridization with subgingival samples of patients with periodontitis and healthy subjects (4), oral bacterial species were categorized into three microbial complexes (yellow, purple, and green), which are described in parentheses in the “Group” column. Whereas most Streptococcus species are representative of species of the yellow complex, P. gingivalis is representative of species of the red complex. The red complex is primarily found in deeper periodontal pockets and its presence is usually preceded by species of the more diverse orange complex. In contrast, those of the yellow complex are considered to be generally associated with healthy sites. MIC, minimum inhibitory concentration; NA, not allocated to any complex.