TABLE 1.
Overview of selected proteins detected in the Pel biofilm associated with either infection or biofilm development
| Locus tag | Protein name | Protein function | Mean log2 fold change (relative to NuoC) | Ref |
|---|---|---|---|---|
| PA14_34870 | ChiC | Not known, possibly involved in cleavage and/or binding to carbohydrates. | 5.50 | –a |
| PA14_26020 | Lap/PaAP/PepB | Secreted protease regulated by quorum sensing (LasRI). One of the most abundant proteins in the biofilm matrix and important for biofilm development. | 4.05 | (38, 39) |
| PA14_31290 | LecA (lectin A; PA-IL) | Adhesion, binding of host glycans and biofilm development. | 3.91 | (40, 41) |
| PA14_16250 | LasB (elastase) | Immune evasion, cleavage of immune effectors, and inhibition of immune cells. | 3.70 | (6, 7, 42) |
| PA14_65000 | Azu | Secreted blue copper bound protein involved in the copper homeostasis of P. aeruginosa. The protein has also been shown to induce apoptosis in macrophages and cancer cell lines. | 3.57 | (43–48) |
| PA14_61200 | CdrA | Extracellular adhesin promoting stability and aggregation of the biofilms Psl and Pel. | 3.54 | (49, 50) |
| PA14_53250 | CbpD | Functions in immune evasion. | 3.36 | (9, 10) |
| PA14_50290 | FliC | Flagellin, the minor subunit that polymerizes to form the flagella. | 3.29 | (51, 52) |
a
Note that “–" represents a lack of available references pinpointing the specific function of the protein.