Figure 2.

ROC curves for (A) model 1, trained on EPIC probes using placental DNAm data from 72 smokers and 24 never-smokers in the VCSIP RCT and applied to the ELGAN dataset ($n=399$), and (B) model 2, trained on 450K probes and applied to the RICHS dataset ($n=237$). Note: AUC, area under the ROC curve; ELGAN, Extremely Low Gestational Age Newborn; EPIC, Infinium MethylationEPIC array; RCT, randomized controlled trial; RICHS, Rhode Island Children’s Health Study; ROC, receiver operating characteristic; VCSIP, Vitamin C to Decrease the Effects of Smoking in Pregnancy on Infant Lung Function.