Table 1.

Randomized clinical trials comparing complete revascularization vs. culprit-only lesion revascularization strategies.

Study, years	Sample size	NCLs severity	Primary outcome	Main result
PRAMI, 2013	465	angiographic diameter stenosis >50%	MACE: CV death, non-fatal MI, refractory angina at 23 months FU	Complete multivessel PCI of NCLs was associated with reduced risk of MACE compared to culprit-only PCI
CvLPRIT, 2015	296	Angiography diameter stenosis >70% or >50% in 2 views	MACE: Death, MI, any repeat revascularization, HF at 12 months FU.	Complete multivessel PCI was associated with lower risk of MACE compared to culprit-only PCI
DANAMI-3 PRIMULTI, 2015	627	Angiography diameter stenosis >90% or Angiography diameter stenosis >50% and FFR<0.80	MACE: Death, re-infarction, ischemia-driven revascularization at 27 months FU.	Complete multivessel PCI guided by FFR reduced the risk of MACE compared with no further invasive intervention after primary PCI
COMPARE-ACUTE, 2017	885	Angiography diameter stenosis>50% and FFR<0.80	MACE: Death, non-fatal MI, revascularization, cerebrovascular events at 12 months FU	Complete multivessel PCI guided by FFR reduced the risk of MACE compared to culprit-only PCI
COMPLETE, 2019	4041	Angiography diameter stenosis >70% or angiography diameter stenosis between 50% and 69% and FFR <0.80	Coprimary outcome 1. Composite of CV death and MI 2. Composite of CV death, MI, and ischemia-driven revascularization at 36 months FU	Complete multivessel PCI reduced the risk of both coprimary outcome compared to culprit-only PCI

CV, cardiovascular; FFR, fractional flow reserve; FU, follow-up; HF, heart failure; MI, myocardial infarction; MACE, major adverse cardiac events; MVD, multivessel disease; NCLs, non-culprit lesions; PCI, percutaneous coronary intervention.