Table 1.

Main results of descriptive analysis of DS and control group excluding strong outliers.

	DS (n = 164)					Control (n = 54)
	THF (ng/mL)	5-methyl-THF (ng/mL)	5-formyl-THF (pg/mL)	SAH (ng/mL)	SAM (ng/mL)	THF (ng/mL)	5-methyl-THF (ng/mL)	5-formyl-THF (pg/mL)	SAH (ng/mL)	SAM (ng/mL)
Valid n =	108	140	79	94	24	41	34	21	19	15
Missing n =	56	24	85	70	140	13	20	33	35	39
Mean	41.574	50.247	151.675	6.588	10.308	57.783	45.369	145.917	1.911	8.022
Median	33.955	49.766	137.955	6.298	9.514	51.471	42.744	139.144	1.736	5.222
SD	29.414	9.358	29.300	2.923	4.237	32.645	12.301	15.413	1.213	6.362

The values of subjects with Down syndrome (DS) are reported on the left of the table and the values of normal control subjects (control) are reported on the right of the table. For each metabolite the number (n) of plasma samples valid or missing are reported. Also the mean, median and standard deviation (SD) values are shown. The detailed results of descriptive analysis with and without strong outliers are shown in Supplementary Table 6.