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. Author manuscript; available in PMC: 2024 Jul 2.
Published in final edited form as: Proteoglycan Res. 2023 Aug 9;1(3):e9. doi: 10.1002/pgr2.9

FIGURE 6.

FIGURE 6

2-O-sulfated heparan compounds attenuate corneal infection by a clinical keratitis isolate of Streptococcus pneumonia. Injured mouse corneas were coinfected with (A) 4 × 108 cfu of the clinical keratitis isolate IDI30/44 (mean ± SE, n = 4–10, **p < 0.01, ***p < 0.001) or (B) 2× 108 cfu of L82016 and PBS (control) or 300 ng of NDS-HP, 2ODS-HP, H, NS-H, or NS2OS-H, and the corneal bacterial burden was enumerated at 6 h pi (mean ± SE, n = 6–8, *p < 0.05). 2ODS-HP, 2-O-desulfated heparin; HP, heparin; NDS-HP, N-desulfated heparin; NS-H, N-sulfated H; NS2OS-H, N- and 2-O-sulfated H; pi, postinfection.