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. 2024 Jun 20;20(6):e1011569. doi: 10.1371/journal.ppat.1011569

Fig 4. LALA-PG substitutions eliminate or severely attenuate antibody-dependent cellular phagocytosis (ADCP).

Fig 4

(A-C) ADCP activity against NTD and mutant NTD_ADEm3 for G1m17, LALA-PG and DLE versions of DH1052 was determined in a THP-1 cell-based assay. Values shown are the mean of two technical replicates. ADCP score is a ratio of the fluorescence of the test result to the no antibody control (PBS). (D) A comparison of ADCP activity of WT NTD for all versions of DH1052 is shown. (E-G) ADCP of NTD and NTD_ADEm3 by G1m17, LALA-PG and DLE versions of DH1050.1 are shown. (H) A comparison of ADCP of Wuhan-Hu-1 NTD for all DH1050.1 versions is shown.