Table 2.
Excerpt of supplemental data file
| Ossabaw Minipig |
Göttingen Minipig |
||||
|---|---|---|---|---|---|
| Annotated Sequence | Sequence Length | Altered bp/Mbp | Variants/Mbp | Altered bp/Mbp | Variants/Mbp |
| α1-Adrenoceptor | |||||
| ADRA1A | 17,143 | 31,383 | 4,958 | 5,483 | 1,167 |
| ADRA1B | 3,280 | 305 | 305 | 230,488 | 3,354 |
| ADRA1D | 1,713 | 0 | 0 | 674,839 | 3,503 |
| α2-Adrenoceptor | |||||
| ADRA2A | 1,353 | 0 | 0 | 294,161 | 8,130 |
| ADRA2B | 1,341 | 0 | 0 | 68,606 | 9,694 |
| ADRA2C | 2,038 | 0 | 0 | 869,480 | 3,435 |
| β-Adrenoceptor | |||||
| ADRB1 | 1,410 | 0 | 0 | 807,092 | 2,837 |
| ADRB2 | 2,688 | 0 | 0 | 154,390 | 2,604 |
| ADRB3 | 3,333 | 0 | 0 | 318,032 | 2,700 |
| Cholinergic receptor muscarinic 3 | |||||
| CHRM3 | 25,105 | 438 | 279 | 8,086 | 956 |
| Nitric oxide synthase | |||||
| NOS1 | 11,467 | 0 | 0 | 33,226 | 3,052 |
| NOS2 | 6,013 | 4,324 | 998 | 69,849 | 2,994 |
| NOS3 | 4,016 | 0 | 0 | 547,809 | 8,964 |
| Gq protein | |||||
| GNA11 | 1,083 | 0 | 0 | 128,347 | 3,693 |
| GNA12 | 6,478 | 309 | 309 | 198,827 | 3,550 |
| GNA13 | 6,309 | 0 | 0 | 87,177 | 793 |
| GNA14 | 2,209 | 0 | 453 | 21,277 | 1,811 |
| GNA15 | 6,141 | 0 | 0 | 71,812 | 4,397 |
| GNB1 | 3,123 | 0 | 0 | 152,097 | 3,842 |
| GNB2 | 2,651 | 0 | 0 | 102,980 | 5,658 |
| GNB3 | 3,710 | 0 | 0 | 354,178 | 6,469 |
| GNB4 | 5,827 | 0 | 0 | 39,986 | 1,201 |
| GNB5 | 4,009 | 0 | 0 | 92,043 | 2,744 |
Altered base pairs and variants in Ossabaw minipigs and Göttingen minipigs, published in Kleinbongard et al. (35). Altered base pairs (bp) and variants in Ossabaw minipigs and Göttingen minipigs for the proteins, which are potentially involved in vasoconstriction to norepinephrine and endothelium-dependent and -independent vasodilation. Protein-encoding genes with a higher number of altered bp and/or variants in Ossabaw minipigs than in Göttingen minipigs where shown in boldface.