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. 2024 Jul 1;8(3):036102. doi: 10.1063/5.0203028

FIG. 1.

FIG. 1.

CD44KO cells exert more traction force than WT cells on collagen-coated surfaces. (a) Traction stress magnitude map comparison of WT and CD44KO on 4.6 kPa collagen-coated gel. In both cases, a phase contrast image of the cell is on the left and traction stress map is on the right. (b) Traction strain energy of WT and CD44KO as a function of substrate stiffness. For 4.6 kPa: n = 53 on WT, n = 59 on CD44KO; for 9.3 kPa: n = 59 on WT, n = 60 on CD44KO; and for 20 kPa: n = 59 on WT, n = 46 on CD44KO. (c) Traction strain energy of WT untreated, CD44 blocked, and integrin blocked on 4.6 kPa collagen. For untreated, CD44 blocked, integrin blocked on collagen, n = 96, 97, and 33, respectively. (d) Cell area of WT untreated, CD44 blocked, and integrin blocked on 4.6 kPa collagen. The red line shows the median. P calculated by the Mann–Whitney test. * denotes P < 0.05, ** denotes P < 0.01, *** denotes P < 0.001, and **** denotes P < 0.0001.