Table 1.
Possible targets of MIc in CCA.
| No. | Targets | Description |
|---|---|---|
| 1 | CYP2D6 | Cytochrome P450 2D6 |
| 2 | TPH1 | Tryptophan 5-hydroxylase 1 |
| 3 | SIRT1 | NAD-dependent deacetylase sirtuin 1 |
| 4 | PTGER1 | Prostanoid EP1 receptor |
| 5 | AGTR1 | Type-1 angiotensin II receptor |
| 6 | CASR | Calcium sensing receptor |
| 7 | SRC | Tyrosine-protein kinase SRC |
| 8 | LCK | Tyrosine-protein kinase LCK |
| 9 | MAPK14 | MAP kinase p38 alpha |
| 10 | KDR | Vascular endothelial growth factor receptor 2 |
| 11 | ITGA4 | Integrin alpha-4 |
| 12 | VDR | Vitamin D receptor |
| 13 | RORC | Nuclear receptor ROR-gamma |
| 14 | NR3C1 | Glucocorticoid receptor |
| 15 | GRB2 | Growth factor receptor-bound protein 2 |
| 16 | BCL2L1 | Apoptosis regulator Bcl-X |
| 17 | RRM1 | Ribonucleoside-diphosphate reductase M1 chain |
| 18 | PPM1A | Protein phosphatase 2C alpha |
| 19 | PTPA | Protein phosphatase 2A regulatory subunit B′ |
| 20 | PTPN6 | Protein-tyrosine phosphatase 1C |
| 21 | METAP2 | Methionine aminopeptidase 2 |
| 22 | CASP3 | Caspase-3 |
| 23 | F10 | Thrombin and coagulation Factor X |
| 24 | MMP9 | Matrix metalloproteinase 9 |
| 25 | CASP7 | Caspase-7 |
| 26 | CASP8 | Caspase-8 |
| 27 | DPP4 | Dipeptidyl peptidase IV |
| 28 | MME | Neprilysin |
| 29 | F2 | Thrombin |
| 30 | ACE | Angiotensin-converting enzyme |
| 31 | DNMT3B | DNA (cytosine-5)-methyltransferase 3B |
| 32 | IL2 | Interleukin-2 |
| 33 | TLR9 | Toll-like receptor (TLR7/TLR9) |
| 34 | GLI1 | Zinc finger protein GLI1 |
| 35 | JUN | Proto-oncogene c-JUN |
| 36 | STAT3 | Signal transducer and activator of transcription 3 |
| 37 | TYMS | Thymidylate synthase |