Fig. 1.

PD-L1 (CD274) and CXCL10 levels are correlated in cancer patients, both of which were also associated with better immunotherapeutic efficacy. A GEPIA was used to investigate the gene expression, including CD274, ICAM1, CXCL10, and IFNs-regulated ISG15, in patients with lung cancer, liver cancer (LIHC), and colorectal cancer (COAD) based on the TCGA database. Red: tumor (T); Gray: non-tumor (N). B cBioPortal was used to validate the correlation expression among CD274, ICAM1, and CXCL10 in LUAD and LIHC. C and D Kaplan–Meier plotter was used to investigate the association among CD274, ICAM1, and CXCL10 levels with immunotherapeutic efficacy in patients with all cancers (n = 454), non-small cell lung cancer (NSCLC, n = 21), and hepatocellular carcinoma (HCC, n = 22). OS, overall survival. *p < 0.05