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. 2024 Jul 2;14:15097. doi: 10.1038/s41598-024-66131-9

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of serum IL-17A (a_i) and IL-23A (a_ii) levels between GAD patients and healthy controls. Data were presented as mean ± SD and analyzed by two tailed unpaired t test to determine the statistical level of significance between mean difference of two groups where p < 0.05 is considered to be statistically significant. [*] represents p < 0.05 and [***] represents p < 0.001. Scatter diagram of GAD-7 scores vs serum IL-17A levels (b_i) and serum IL-23A levels (b_ii) in the patient group were presented. Pearson correlation analysis was performed to find out the potential association between serum cytokine levels and GAD-7 scores of GAD patients. Both the male (red colored circular point) and female (blue colored rectangular point) GAD patients showed significant association between IL-17 or IL-23 serum levels and GAD-7 scores.