Fig. 5. Dimer formation and transport activity of hSVCT1.

a–b Representations of dimer interfaces in (a) inward-open state and (b) substrate-free occluded state, viewed from the intracellular side. c–f Close-up views of the residues responsible for dimer formation in (c–d) inward-open state and (e–f) substrate-free occluded state. g Evaluation of oligomeric population of dimer interface mutants by FSEC, detected by GFP fluorescence. h Substrate uptake assay for dimer interface mutants. Values are mean of n = 3 biological replicates ± s.e.m. compared relative to the wild-type uptake rate. Source data are provided as a Source Data file.