Table 2.

Transcription factor partners of Runx2.

Co-activator	Role	Co-repressor	Role
Cbfβ	Enhances Runx protein binding to DNA Stabilizes Runx by inhibiting ubiquitination-mediated degradation	Hey1	Negatively regulates Runx2 by binding with Runx2 to suppress it
SIRT1	Interacts with Runx2 and promotes its trans-activation potential	Smurf1/2	Degrades Runx2 by ubiquitination-mediated proteasome degradation pathway
TAZ	Stimulates osteogenic differentiation via interacting with Runx2	COUP-TFII	Impairs Runx2-dependent osteocalcin promoter activation
P300	Positively regulates Runx2 by mediating Runx2 acetylation	Grg/TLE	Inhibits Runx2-dependent transcriptional activation of OCN genes
VGLL4	Breaks TEAD-mediated Runx2 transcriptional inhibition	EGFR	Increases the content of transcription corepressor HDAC4 and HDAC6 and inhibits the expression of Runx2