TABLE 3.
Replication of the attenuated rcp45L(HA) viruses in the upper and lower respiratory tract of hamsters
| Virusa | No. of animals | Virus titer (log10 TCID50/g ± SE) (Tukey-Kramer grouping)b
|
|
|---|---|---|---|
| Nasal turbinates | Lungs | ||
| rcp45L | 6 | 4.7 ± 0.2 (A) | 2.9 ± 0.1 (A) |
| rcp45L(HA N-P) | 6 | 3.7 ± 0.2 (B) | 2.9 ± 0.1 (A) |
| rcp45L(HA P-M) | 7 | 3.7 ± 0.1 (B) | 2.9 ± 0.2 (A) |
| rJS | 7 | 6.5 ± 0.1 (C) | 5.6 ± 0.2 (B) |
a
Animals received 106 PFU of the indicated virus intranasally in a 0.1-ml inoculum, and the lungs and nasal turbinates were harvested 4 days later.
b
Mean virus titers were assigned to statistically similar groups (A to C) by the Tukey-Kramer test. Therefore, means in each column with different letters are significantly different (α = 0.05), and those with the same letter are not significantly different.