TABLE 4.
rPIV3(HA) viruses elicit moderate to high levels of serum antibodies to both measles virus and PIV3
| Virusa | Serum antibody response to measles virus (60% PRNT, mean reciprocal log2 ± SE) (Tukey-Kramer grouping)b
|
Serum antibody response to human PIV3 (HAI titer, mean reciprocal log2 ± SE) (Tukey-Kramer grouping)b
|
||
|---|---|---|---|---|
| Day −1 | Day 30 | Day −1 | Day 30 | |
| rPIV3(HA N-P) | ≤3.3 ± 0 (A) | 14.8 ± 0.3 (A) | ≤2.0 ± 0 (A) | 9.0 ± 0.4 (A) |
| rPIV3(HA P-M) | ≤3.3 ± 0 (A) | 15.3 ± 0.3 (A) | ≤2.0 ± 0 (A) | 9.0 ± 0.0 (A) |
| rPIV3(HA HN-L) | ≤3.3 ± 0 (A) | 6.1 ± 0.7 (B) | ≤2.0 ± 0 (A) | 9.4 ± 0.3 (A) |
a
Virus was administered at a dose of 106.0 PFU to hamsters in a 0.1-ml inoculum intranasally on day 0. Each group contained eight animals.
b
Mean HAI and neutralizing antibody titers were assigned to statistically similar groups (A or B) by the Tukey-Kramer test. Therefore, means in each column with different letters are significantly different (α = 0.05), and means with the same letter are not significantly different.