TABLE 5.
rcp45L(HA) viruses elicit high levels of serum antibodies to both measles virus and PIV3
| Virusa | No. of animals | Serum antibody response to measles virus (60% PRNT, mean reciprocal log2 ± SE) (Tukey-Kramer grouping)b
|
Serum antibody response to PIV3 (HAI titer, mean reciprocal log2 ± SE) (Tukey-Kramer grouping)b
|
||
|---|---|---|---|---|---|
| Day −1 | Day 25 | Day −1 | Day 25 | ||
| rcp45L(HA P-M) | 24 | ≤3.3 ± 0 (A) | 12.8 ± 0.1 (A) | ≤2.0 ± 0 (A) | 9.2 ± 0.2 (B) |
| rcp45L(HA N-P) | 6 | ≤3.3 ± 0 (A) | 13.4 ± 0.4 (A) | ≤2.0 ± 0 (A) | 10.8 ± 0.3 (A) |
| rPIV3(HA P-M) | 6 | ≤3.3 ± 0 (A) | 13.3 ± 0.3 (A) | ≤2.0 ± 0 (A) | 10.3 ± 0.2 (A) |
| rcp45L | 18 | ≤3.3 ± 0 (A) | ≤3.3 ± 0 (B) | ≤2.0 ± 0 (A) | 10.3 ± 0.2 (A) |
| rJS | 6 | ≤3.3 ± 0 (A) | ≤3.3 ± 0 (B) | ≤2.0 ± 0 (A) | 10.7 ± 0.2 (A) |
| Measles virus (Moraten)c | 4 | ≤3.3 ± 0 (A) | 10.8 ± 0.2 (C) | ≤2.0 ± 0 (A) | ≤2.0 ± 0.0 (C) |
Virus was administered at a dose of 106.0 PFU to the indicated number of hamsters in a 0.1-ml inoculum intranasally on day 0 to all animals with the exception of those in the measles virus (Moraten) group.
Mean HAI and neutralization antibody titers were assigned to statistically similar groups (A to C) by the Tukey-Kramer test. Therefore, means in each column with different letters are significantly different (α = 0.05), and means with the same letter are not significantly different.
The live attenuated measles vaccine virus, Moraten strain, was administered intramuscularly at a dose of 105 PFU in a 0.1-ml inoculum to four cotton rats in a separate study and is presented for reference value only.