Table 2.
Causal relationships identified by Mendelian randomization analysis
| Brain iron (exposure) | Diseases (outcome) | Beta | p value | FDR |
|---|---|---|---|---|
| Subthalamic nucleus (right) | Bipolar | 0.011 | 3.59E−07 | 2.15E−05 |
| Accumbens (left) | Bipolar | 0.023 | 3.11E−05 | 9.33E−04 |
| Substantia nigra (right) | PD | 0.010 | 1.45E−04 | 2.90E−03 |
| Substantia nigra (left) | PD | 0.011 | 1.33E−03 | 1.92E−02 |
| Caudate (right) | PD | 0.013 | 1.60E−03 | 1.92E−02 |
| Dentate (right) | PD | 0.006 | 4.25E−03 | 4.25E−02 |
| Putamen (left) | PD | 0.010 | 5.11E−03 | 4.34E−02 |
| Thalamus (left) | Bipolar | 0.024 | 5.79E−03 | 4.34E−02 |
| Putamen (right) | PD | 0.010 | 6.71E−03 | 4.47E−02 |
| Subthalamic nucleus (right) | Depression | 0.003 | 7.67E−03 | 4.60E−02 |
| Hippocampus (right) | Depression | 0.017 | 8.49E−03 | 4.63E−02 |
The iron in brain regions are the exposure variables and the brain disorders are the outcome variables.