Fig. 6.

Impact scores identify individuals vulnerable to poor outcomes following the unpredictability dimension of early-life adversity. A) Flow chart of the computation method used to select highly contributing sites. The clumping and thresholding method identifies sites that appear to have a significant interaction but do not correlate highly with other sites that have already been selected. B) Manhattan plot representing the differentially methylated sites (blue) and the distribution across the chromosomes and the corresponding significance score (-log10p) of each site interacting with QUIC to predict effortful control in females. Sites in red are those selected via the clumping and thresholding algorithm. Dotted line is at p = 0.05. C) The significant interaction of QUIC and risk score calculated from top sites according to our model predicts effortful control at 5 years in females who have experienced more adversity n: low = 28, high = 13. Line represents linear regression. R and p represent Pearson correlation for subgroup. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)