Table 2.
CDR3 sequences and their frequencies of the top5 TCRs from CRC patients
| TCR | TRAV | TRAJ | TRA-CDR3 | TRBV | TRBD | TRBJ | TRB-CDR3 | TIL alone (Freq%) | PDO(T)-oeT (Freq%) |
|---|---|---|---|---|---|---|---|---|---|
| CRC1 | |||||||||
| TCR1 | TRAV35*02 | TRAJ10*01 | AGVTGGGNKLT | TRBV6-1*01 | TRBD1*01 | TRBJ1-2*01 | ASSEGTGFYGYT | 4.3 | 25.6 |
| TCR2 | TRAV35*02 | TRAJ 10*01 | AGVTGGGNKLT | TRBV28*01 | TRBD2*01 | TRBJ2-2*01 | ASSLTSASGELF | 3.6 | 17.8 |
| TCR3 | TRAV24*01 | TRAJ12*01 | APWMDSSYKLI | TRBV28*01 | TRBD1*01 | TRBJ1-2*01 | ASSIGGHDGYT | 2.5 | 6.7 |
| TCR4 | TRAV8-3*02 | TRAJ15*01 | AVGAQAGRNCSD | TRBV20-1*01 | TRBD1*01 | TRBJ2-7*01 | SASPQSYEQY | 1.2 | 5 |
| TCR5 | TRAV36/DV7*04 | TRAJ30*01 | AVSRDDKII | TRBV6-5*01 | TRBD2*01 | TRBJ2-2*01 | ASSYVGNTGELF | 1.2 | 5 |
| CRC2 | |||||||||
| TCR6 | TRAV8-3*01 | TRAJ21*01 | AVGDNFNKFY | TRBV28*01 | TRBD1*01 | TRBJ2-2*01 | ASSYVGNTGELF | 1.1 | 13.4 |
| TCR7 | TRAV14/DV4*03 | TRAJ24*03 | AMREGADSWGKFQ | TRBV28*01 | TRBD1*01 | TRBJ1-4*01 | ASSLHGRGDEKLF | 0.5 | 12.4 |
| TCR8 | TRAV23/DV6*01 | TRAJ45*01 | ALKAGGGASKLT | TRBV9*01 | TRBD2*02 | TRBJ2-1*01 | ASSVGGGVDEQF | 2.8 | 9.3 |
| TCR9 | TRAV1-2*01 | TRAJ6*01 | AVRGTLSGGSYIPT | TRBV28*01 | TRBD1*01 | TRBJ2-2*01 | ASSATSASGELF | 1.1 | 8.2 |
| TCR10 | TRAV13-1*01 | TRAJ42*01 | AASPPGGSQGNLI | TRBV4-1*01 | TRBD2*01 | TRBJ2-1*01 | ASSHRTSSRGEQF | 0.5 | 3.1 |
| CRC3 | |||||||||
| TCR11 | TRAJ27*01 | TRAJ27*01 | AVSGVGKST | TRBV7-9*01 | TRBD1*01 | TRBJ2-1*01 | ASSPPQGATYNEQF | 0.4 | 11.4 |
| TCR12 | TRAV10*01 | TRAJ16*02 | VSGFSDGQKLL | TRBV10-3*02 | TRBD1*01 | TRBJ2-1*01 | ATTKTGERPDEQF | 1.3 | 8 |
| TCR13 | TRAV14/DV4*01 | TRAJ45*01 | ANDSGGGADGLT | TRBV20-1*01 | TRBD2*02 | TRBJ2-1*01 | SARGLLGGRAREQF | 3 | 4 |
| TCR14 | TRAV10*01 | TRAJ4*01 | VVSFSGGYNKLI | TRBV9*01 | TRBJ1-2*01 | TRBD1*01 | ASSVGDRDYGYT | 0 | 4 |
| TCR15 | TRAV8-6*02 | TRAJ20*01 | AVSGRSNDYKLS | TRBV6-1*01 | TRBD1*01 | TRBJ1-3*01 | ASSEKRQGAGNTIY | 0.4 | 3 |
| CRC4 | |||||||||
| TCR16 | TRAV8-2*01 | TRAJ43*01 | AVSDLGNDMR | TRBV10-3*01 | TRBD2*01 | TRBJ2-3*01 | AISGGAGATDTQY | 4 | 31 |
| TCR17 | TRAV20*01 | TRAJ4*01 | AVFSGGYNKLI | TRBV12-3*01 | TRBD2*01 | TRBJ1-5*01 | ASSLEFYSNQPQH | 2.4 | 13.5 |
| TCR18 | TRAV3*01 | TRAJ31*01 | AVRDEGARLM | TRBV9*01 | TRBD1*01 | TRBJ2-3*01 | ASSIFSGTGGADTQY | 0 | 10.3 |
| TCR19 | TRAV22*01 | TRAJ26*01 | AVGRGYGQNFV | TRBV4-3*01 | TRBD1*01 | TRBJ1-4*01 | ASSQDGGLNEKLF | 0 | 7.7 |
| TCR20 | TRAV13-2*01 | TRAJ8*01 | AENMGFQKLV | TRBV30*01 | TRBD1*01 | TRBJ1-2*01 | AWTQGANGYT | 0 | 7.1 |