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. 2024 Jun 29;29:2610. doi: 10.4102/hsag.v29i0.2610

TABLE 4a.

Associations between maternal iron status at early and mid-pregnancy with systolic blood pressure in late pregnancy (multivariable linear regression).

Gestational age Predictor Systolic blood pressure (mmHg)
Model 1 (n = 190)
Model 2 (n = 189)
Model 3
B 95% CI p B 95% CI p B 95% CI p
< 18 weeks Hb (g/dL) −0.46 −1.46, 0.53 0.358 −0.87 −1.87, 0.13 0.089 - - -
Fer (μg/L) −0.01 −0.02, 0.01 0.376 −0.01 −0.02, 0.01 0.273 - - -
sTfR (mg/L) 0.04 −0.15, 0.22 0.709 0.08 −0.10, 0.26 0.407 - - -
Model 1 (n = 189) Model 2 (n = 188) Model 3 (n = 188)
22 weeks Hb (g/dL) −1.04 −2.06, -0.02 0.046 −1.10 −2.11, -0.09 0.033 −0.75 −1.59, 0.09 0.081
Fer (μg/L) −0.01 −0.04, 0.02 0.660 −0.02 −0.04, 0.01 0.310 −0.01 −0.03, 0.02 0.695
sTfR (mg/L) −0.03 −0.33, 0.27 0.858 −0.03 −0.32, 0.28 0.831 −0.07 −0.31, 0.17 0.566

CI, confidence interval; Hb, haemoglobin; Fer, serum ferritin; sTfR, soluble transferrin receptor. Associations were assessed with multivariable linear regression, B-values and 95% confidence intervals. Model 1 is adjusted for maternal age and living standards measure (socio-economic status); model 2 is adjusted additionally for gestational age, CRP and maternal BMI at baseline, HIV status throughout pregnancy and aspirin prescription during mid-pregnancy; model 3 is adjusted additionally for blood pressure at ± 22 weeks’ gestation. p < 0.05 was considered significant and p between 0.05 and 0.08 had a tendency towards significance.