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. 2024 Jun 19;15:1355269. doi: 10.3389/fphar.2024.1355269

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Copyright © 2024 Lin, Yang, Wang, Huang, Wang, Chen, Xu, Cai, Khan, Liu and Lin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Therapeutic implications (A) Pearson’s correlation between riskScore and several immune checkpoint inhibitors. p values are shown as: *p < 0.05; **p < 0.01; ***p < 0.001. (B) Association between riskScore and TIDE score of TCGA STAD patients. (C) The Kaplan-Meier curves of difference in survival probability between risk subgroups and (D) boxplots of riskScore variation in responsiveness to immune checkpoint blockade of IMvigor210 urothelial carcinoma cohort. (E) Box plot of association of microsatellite instability (MSI) and riskScore. (F) Percent of MSI types in each risk subgroup. (G) Drug sensitivity analysis of risk subgroups.