Table 3. Recommended oral dosages of 3,4-DAP and 3,4-DAPP for the treatment of LEMS.

Body weight		Initial dosage	Titration regimen	Maximum single dose	Maximum total daily dose
3,4-DAPP (Firdapse)
	≥45 kg*	10–15 mg/day, in 3 or 4 divided doses	Increase total daily dose by 5 mg every 3–4 days	20 mg	80 mg, given in divided doses
	<45 kg	5–15 mg/day, in 3 or 4 divided doses	Increase total daily dose by 2.5 mg every 3–4 days	10 mg	40 mg, given in divided doses
3,4-DAP (Ruzurgi)†
	≥45 kg	15–30 mg/day, in 2 or 3 divided doses	Increase daily in 5- to 10-mg increments, divided in up to 5 daily doses	30 mg	100 mg
	<45 kg	7–15 mg/day in 2 or 3 divided doses	Increase daily in 2.5- to 5-mg increments, divided in up to 5 daily doses	15 mg	50 mg

^*Same as adult (any weight); ^†Recommended previously by Ruzurgi.

3,4-DAP, 3,4-diaminopyridine; 3,4-DAPP, 3,4-diaminopyridine phosphate; LEMS, Lambert-Eaton myasthenic syndrome.