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The one-carbon (1C) metabolism regulates the synthesis of purine, amino acids, and phospholipids to maintain the redox homeostasis and rapid cell growth. Cancer cells enhance the biosynthesis of amino acid serine and glycine. The amino acids are used as donors of one carbon unit, the 1C meta- bolism transfers this carbon unit for the biosynthesis of various metabolic outputs, such as nucleotides and redox homeostasis by folate and methio- nine cycles.
