Table 2.

Currently available skin substitutes

Type of skin substitute	Composition	Current status
Epidermal	Cultured autologous epidermal cells	Used for severe burn injuries
	Cultured allogeneic epidermal cells	Used for severe burn injuries
Dermal:
Alloderm	Acellular allogeneic human skin	Approved for treating burns
Integra	Bovine collagen with chondroitin 6-sulfate	Approved for treating burns
Dermagraft-TC	Fibroblasts on nylon mesh	In clinical trials for treating diabetic foot ulceration
Combined epidermal and dermal:
Apligraf	Bovine collagen, allogeneic fibroblasts, and epidermal cells	Licensed for treating diabetic foot ulcers and venous leg ulcers
Composite Cultured Skin	Collagen matrix substrate with fibroblasts and epidermal cells	In trials