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Semilogarithmic plot of concentration–time profiles of siponimod in the vitreous after intravitreal injection of low-dose (1300 ng) (A,B) and high-dose siponimod (6500 ng) (C,D). B,D show the terminal elimination phase. Data are presented as the mean concentration at each time point, and graphs were generated using the PKSolver 2.0 add-in program for Microsoft Excel.
