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. 2024 Jun 10;21(7):3310–3320. doi: 10.1021/acs.molpharmaceut.4c00063

Figure 3.

Figure 3

Representative retinal sections were stained with H&E 24 h (A–D) and 7 days (E,F) after intravitreal injection. (A) Untreated control, (B) vehicle control, (C) low dose siponimod (1300 ng) after 24 h, (D) high dose siponimod (6500 ng) after 24 h, (E) low dose siponimod (1300 ng) after 7 days, and (F) high dose siponimod (6500 ng) after 7 days. The sections show no noticeable difference in retinal morphology between groups. ILM, inner limiting membrane; GC, ganglionic cell layer; IPL, inner plexiform layer; INL, inner nuclear layer; OPL, outer plexiform layer; ONL, outer nuclear layer; IS, inner segment of photoreceptors; OS, outer segments of photoreceptors. Scale bar = 0.05 mm.