Representative
retinal sections were stained with H&E 24 h
(A–D) and 7 days (E,F) after intravitreal injection. (A) Untreated
control, (B) vehicle control, (C) low dose siponimod (1300 ng) after
24 h, (D) high dose siponimod (6500 ng) after 24 h, (E) low dose siponimod
(1300 ng) after 7 days, and (F) high dose siponimod (6500 ng) after
7 days. The sections show no noticeable difference in retinal morphology
between groups. ILM, inner limiting membrane; GC, ganglionic cell
layer; IPL, inner plexiform layer; INL, inner nuclear layer; OPL,
outer plexiform layer; ONL, outer nuclear layer; IS, inner segment
of photoreceptors; OS, outer segments of photoreceptors. Scale bar
= 0.05 mm.