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Impact of temperature on the stability of siponimod in solution over time. Graphs show the change in siponimod concentration (in μg/mL) in the solution stored over time (days) at refrigerator temperature (4 °C), room temperature (25 °C), 40, and 60 °C. Three samples were analyzed at each temperature, and the experiment was repeated 3 times (n = 3, independent replicates). Data are presented as the mean ± SD.
