Table 2. Mean Siponimod Concentrations in the Vitreous Samples Obtained at Different Time Points for Low and High Doses of the Druga.
| time (h) | low dose
siponimod (1300 ng) |
high dose (6500 ng) |
||
|---|---|---|---|---|
| mean concentration ± (SD) (ng/mL) | number of rabbits (n) | mean concentration ± (SD) (ng/mL) | number of rabbits (n) | |
| 0.5 | 314.1 (7.4) | 5 | 3161.7 (387.1) | 2 |
| 1 | 515.6 (42.6) | 4 | 2156.3 (268.5) | 3 |
| 2 | 487.9 (41.5) | 5 | 1730.3 (673.9) | 3 |
| 4 | 171.0 (12.8) | 5 | 1489.7 (509.5) | 3 |
| 6 | 92.9 (12.6) | 3 | — | — |
| 8 | 53.9 (3.5) | 5 | 457.6 (325.6) | 3 |
| 10 | 39.4 (31.3) | 3 | 322.5 (187.3) | 3 |
| 16 | nd | 3 | 162.8287 (88.377) | 3 |
| 24 | — | — | nd | 3 |
a
Values are presented as mean concentration ± standard deviation (SD), nd: not detected using the established HPLC analysis method, n = 2–5 for each time point. The vitreous concentration after injection of the low dose (1300 ng) and high dose of siponimod (6500 ng) was not measured at 24 and 6 h, respectively.