Table 5. Different Mathematical Models to Predict the Vitreous Half-Life (T_1/2) or Clearance (CL_ivt) and Their Application Using Siponimod.

no.	equation	molecular descriptors in the equation	calculated T1/2 or CLivt for siponimoda	references
1	1	MW: molecular weight, P: partition coefficient, and D: distribution coefficient	0.78 h	(48)
2	2		1.16 h
3	3	HD: hydrogen bond donor count, PSA: polar surface area, and Log D7.4: distribution coefficient measured at 7.4	0.75 mL/h	(49)
4	4		0.52 mL/h
5	5	Log D7.4: distribution coefficient measured at 7.4, Htot: total hydrogen bond count, and FRB: freely rotating bond count	3.14 h	(50)

^aT_1/2 was calculated in hours (h) using eqs 1, 2 and 5 and CL_ivt was calculated in mL/h using eqs 3 and 4. Siponimod molecular descriptors are summarized in Table 4.