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. 2024 Jul 3;20:288. doi: 10.1186/s12917-024-04053-4

Fig. 5.

Fig. 5

Binding mode between Mpro and luteolin. A Binding patterns between Mpro (PDB: 7W6M) and luteolin. Red box: the candidate binding pocket in Mpro; B Hydrophilic-hydrophobic interactions between luteolin and Mpro in the binding pocket; C Key Mpro residues form binding interactions with the luteolin ligand. The binding free energy between Mpro and luteolin was − 7.36 kcal/mol. D Luteolin effects on Mpro activity. The IC50 was determined in GraphPad. Data are shown as the mean ± standard deviation from three independent experiments