Table 3.

Test for strength, horizontal pleiotropy, and heterogeneity.

Variables	Strength	Horizontal pleiotropy test		Heterogeneity test
	F, R2	MR-Egger intercept	P	MR-Egger Q	P	IVW Q	P
Epilepsy
T1DM	40.459, 0.161	0.0015	0.8299	24.3752	0.5545	24.4223	0.6068
T2DM	33.841, 0.011	0.0037	0.595	67.0296	0.221	67.3541	0.2401
Fasting glucose	54.97, 0.027	0.0082	0.174	58.779	0.4101	60.7329	0.3777
HbAlc	34.378, 0.023	−0.0023	0.7058	81.6014	0.0576	81.7876	0.0663
Focal epilepsy
T1DM	40.459, 0.161	0.0015	0.9351	26.9433	0.4123	26.9503	0.4665
T2DM	33.841, 0.011	0.0176	0.2857	57.0802	0.5466	58.241	0.5403
Fasting glucose	54.97, 0.027	0.0209	0.2337	79.0295	0.0284	81.0381	0.0246
HbAlc	34.378, 0.023	−0.0041	0.7695	67.9049	0.3138	67.9983	0.3428
Generalized epilepsy
T1DM	40.459, 0.161	0.0222	0.1217	30.3232	0.2544	33.3084	0.1871
T2DM	33.841, 0.011	0.0103	0.3853	52.2596	0.7203	53.0246	0.7263
Fasting glucose	54.97, 0.027	0.0103	0.337	36.4496	0.9845	37.387	0.9838
HbAlc	34.378, 0.023	−0.0126	0.2418	74.1395	0.1592	75.7824	0.1488

F = r^{2 *} (N−2)/(1–r²), r² = 2 ^* EAF ^* (1–EAF) ^* b²/SD², MR, Mendelian randomization; IVW, inverse variance weighted; T1DM, type 1 diabetes mellitus; T2DM, type 2 diabetes mellitus; HbAlc, glycated hemoglobin. Bold values represented exposure and outcome related SNPs have heterogeneity.