Table 3. Comparison of Ki-67 labeling index in the low risk and high risk groups in the test set and univariate analysis results for predicting high risk Oncotype DX recurrence score in the test set.
| Variable | Low risk (n = 248) | High risk (n = 52) | p-value | |
|---|---|---|---|---|
| IKWG scoring method (automated Roche) | 13.34 (0.18–60.42) | 22.55 (0.09–63.85) | < 0.0001 | |
| ≤ 20 | 207 (85.4%) | 25 (48.9%) | < 0.0001 | |
| > 20 | 41 (14.6%) | 27 (51.1%) | ||
| IKWG scoring method (automated Roche) | ||||
| ≤ 14 | 155 (66.5%) | 21 (46.7%) | 0.0039 | |
| > 14 | 93 (33.5%) | 31 (53.3%) | ||
| Average QuPath | 7.94 (0.11–35.96) | 13.40 (0.05–38.01) | < 0.0001 | |
| ≤ 10 | 186 (79.1%) | 25 (48.9%) | 0.0002 | |
| > 10 | 62 (20.9%) | 27 (51.1%) | ||
| Hotspot QuPath | 17.35 (2.96–49.15) | 13.85 (2.38–41.1) | 0.195 | |
| ≤ 20 | 175 (70.4%) | 45 (84.4%) | 0.090 | |
| > 20 | 73 (29.6%) | 7 (15.6%) | ||
| Hottest spot QuPath | 20.06 (4.13–56.74) | 17.62 (3.81–45.13) | 0.547 | |
| ≤ 20 | 155 (60.7%) | 35 (62.2%) | 0.786 | |
| > 20 | 93 (39.3%) | 17 (37.8%) | ||
Continuous variable presented as mean (range) and categorical variable presented as number (%).
IKWG = International Ki-67 in Breast Cancer Working Group.