Table 7. Summary of the published studies that used clinicopathologic parameters to predict Oncotype DX recurrence score in Korea and comparison to our current study.
| Variable | Lee et al., 2019 [3] | Yoo et al., 2020 [4] | Kim et al., 2023 [5] | Current study | ||||
|---|---|---|---|---|---|---|---|---|
| Patients | ||||||||
| Training group | 340 | 191 | 175 | 300 | ||||
| Validation group | 145 | 264 | 122 | 117 | ||||
| Clinicopathological parameters included in predictive model | Nuclear grade (1, 2 or 3), ER (Allred score), PR (Allred score), LVI (present or absent), Ki-67 (%) | Nuclear grade (1–2 or 3), PR (negative or positive), Ki-67 (%) | Nuclear grade (1–2 or 3), PR (negative or positive), Ki-67 (%) | Age (≤ 50 or > 50), histologic type (IDCa or others), histologic grade (1 or 2–3), necrosis, PR (negative or positive), Ki-67 (≤ 20% or > 20%) | ||||
| ODX RS cutoff values | ≤ 25 (LR), > 25 (HR) | ≤ 25 (LR), > 25 (HR) | ≤ 25 (LR), > 25 (HR) | Age ≤ 50:≤ 20, Age > 50:≤ 25 (LR) | ||||
| Age ≤ 50: > 20, Age > 50:> 25 (HR) | ||||||||
| (regardless of age) | (regardless of age) | (regardless of age) | ||||||
| Ki-67 scoring method | No detailed explanation, Ki-67 LI (0–100) | No detailed explanation, Ki-67 LI (0–100): | Ki-67 LI (0–100): | Systematic evaluation of Ki-67 scoring methods: | ||||
| Percentage of positive cells by IHC | IKWG scoring method using an automated image analysis program used for pathology reports at their institution | 1) Average vs hotspot vs hottest spot using QuPath | ||||||
| 2) Roche-analyzed Ki-67 scores according to IKWG recommendations | ||||||||
| Type of prediction model | Nomogram | Nomogram | Automatic calculator based on equation | Simplified score: At least three of the six items are applicable from routine pathology report | ||||
| Computational process required | Computational process required | Computational process required | No computational process required | |||||
PR = progesterone receptor; ER = estrogen receptor; IDCa = invasive ductal carcinoma; LVI = lymphovascular invasion; ODX RS = Oncotype DX recurrence score; LR = low risk; HR = high risk; Ki-67 LI = Ki-67 labeling index; IHC = immunohistochemistry; IKWG = International Ki-67 in Breast Cancer Working Group.