Table 4.

Recurrent event analysis using the Prentice, Williams and Peterson Gap-Time model for risk factors associated with haemorrhage in 411 CCMs

Factor	Univariate analysis		Multivariate analysis
	P value	HR (95% CI)	P value	HR (95% CI)
Gender female	0.243	1.21 (0.88 to 1.67)
Familial form	0.821	0.77 (0.06 to 9.43)
Developmental venous anomaly	0.014	1.69 (1.11 to 2.57)	0.022	1.60 (1.07 to 2.40)
Location brainstem vs others	0.022	1.44 (1.05 to 1.96)	0.072	1.31 (0.98 to 1.75)
Prior surgery	0.559	1.18 (0.68 to 2.04)
Stereotactic radiosurgery	<0.0001	0.25 (0.15 to 0.41)	<0.0001	0.27 (0.17 to 0.44)

CCM, cerebral cavernous malformation.