Table 5.

Cox analysis for factor associated with new haemorrhage after SRS in 413 CCMs*

Factor	Univariate analysis		Multivariate analysis
	P value	HR (95% CI)	P value	HR (95% CI)
Gender female	0.68	1.14 (0.61 to 2.13)
Developmental venous anomaly	0.037	2.15 (1.05 to 4.40)	0.049	2.08 (1.00 to 4.31)
Age at SRS >65	0.037	3.02 (1.07 to 8.52)	0.052	2.81 (0.99 to 7.95)
Volume >0.7 cc	0.042	1.94 (1.02 to 3.66)	0.064	1.85 (0.96 to 3.53)
Margin >13 Gy	0.003	2.63 (1.39 to 4.98)	0.012	2.27 (1.20 to 4.32)
Location brainstem vs others	0.65	1.16 (0.62 to 2.15)
Multiple haemorrhages pre-SRS	0.048	1.90 (1.00 to 3.60)	0.071	1.80 (0.95 to 3.42)

*The analysis was performed on 413 CCM, as volumetric measurements on one CCM were missing

CCM, cerebral cavernous malformation; SRS, stereotactic radiosurgery.