Table 3.

Comparison of 7 published case reports of MALA.

Patient factors	Deepak et al. 20098	Sendil et al. 20209	Umeda et al. 201810	Rai et al. 202011	Santoli et al. 202312	Watson et al. 201613	Mikhail et al. 2023
Age	51	63	54	77	62	82	70
Sex	female	male	female	male	male	male	female
Clinical Presentation	Encephalopathy, Abdominal pain	Cardiac arrest	gastroenteritis	Abdominal pain, nausea, vomiting	Abdominal pain, nausea, vomiting	Nausea and vomiting	Encephalopathy
Metformin dosage	1000 mg BID	1000 mg BID	1000 mg BID	1000 mg BID	1000 mg BID	unknown	1000 mg BID
pH level	6.64	6.69	6.57	6.94	6.9	6.5	6.607
Bicarbonate level (mmol/L)	<5	4.8	2	8	5	unknown	2
Creatinine level (mg/dl)	7.4	15.95	8.07	7.39	13.3	unknown	8.4
Lactic acidosis (mmol/L)	23.8	12	16.3	13.1	11.7	28.6	20.1
Metformin level (mcg/ml)	unknown	29	42	23	unknown	unknown	35
Treatment	CRRT	CRRT	CRRT	CRRT	CRRT	CRRT	CRRT