Table 2.
Comparison of the involved cGVHD organ systems between classic cGVHD and ocGVHD at the time of initial presentation (Table 2A) and at maximum severity of cGVHD (Table 2B).
| Number of patients with cGVHD subtype (% of patients with cGVHD subtype compared to total number with cGVHD) | 57 (62%) | 35 (38%) | |
| Skin | 21 (37) | 30 (86) | <0.001a |
| Grade 1 | 10 (18) | 10 (29) | |
| Grade 2 | 6 (11) | 10 (29) | |
| Grade 3 | 5 (9) | 10 (29) | |
| Mouth | 47 (82) | 28 (80) | 0.79b |
| Eyes | 22 (39) | 16 (46) | 0.52b |
| GI | 14 (25) | 19 (54) | 0.002a |
| Grade 1 | 7 (12) | 9 (26) | |
| Grade 2 | 7 (12) | 3 (9) | |
| Grade 3 | 0 (0) | 7 (20) | |
| Liver | 22 (39) | 12 (34) | 0.94a |
| Grade 1 | 9 (16) | 5 (14) | |
| Grade 2 | 12 (21) | 1 (3) | |
| Grade 3 | 1 (2) | 6 (17) | |
| Lungs | 5 (9) | 0 (0) | 0.15b |
| Fascia | 5 (9) | 1 (3) | 0.40b |
| GU | 2 (4) | 1 (3) | >0.99b |
| Other | 23 (40) | 12 (34) | 0.66b |
| Skin | 22 (39) | 32 (91) | <0.001a |
| Grade 1 | 11 (19) | 10 (29) | |
| Grade 2 | 6 (11) | 11 (31) | |
| Grade 3 | 5 (9) | 11 (31) | |
| Mouth | 48 (84) | 29 (83) | >0.99b |
| Eyes | 28 (49) | 18 (51) | >0.99b |
| GI | 19 (33) | 21 (60) | 0.005a |
| Grade 1 | 10 (18) | 10 (29) | |
| Grade 2 | 9 (16) | 2 (6) | |
| Grade 3 | 0 (0) | 9 (26) | |
| Liver | 22 (39) | 14 (40) | 0.73a |
| Grade 1 | 8 (14) | 6 (17) | |
| Grade 2 | 12 (21) | 2 (6) | |
| Grade 3 | 2 (4) | 6 (17) | |
| Lungs | 9 (16) | 1 (3) | 0.08b |
| Fascia | 8 (14) | 1 (3) | 0.15b |
| GU | 4 (7) | 2 (6) | >0.99b |
| Other | 24 (42) | 14 (40) | >0.99b |
*
All p-values reported are nominal p-values with no adjustment for multiplicity of testing.
a
Kruskal-Wallis test by ranks on the distributions of the ordered grades of cGVHD organ involvement.
b
Fisher’s exact test on whether or not there was cGVHD involvement for specified organ system.